Centella asiatica in Dermatology: An Overview

@article{Bylka2014CentellaAI,
  title={Centella asiatica in Dermatology: An Overview},
  author={Wiesława Bylka and Paulina Znajdek-Awiżeń and Elżbieta Studzińska-Sroka and Aleksandra Dańczak‑Pazdrowska and Małgorzata Brzezińska},
  journal={Phytotherapy Research},
  year={2014},
  volume={28},
  pages={1117 - 1124}
}
Centella asiatica is a medicinal plant that was already used as a ‘panacea’ 3000 years ago. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecasosside, asiatic acid and madecassic acid. We have conducted an overview to summarize current knowledge on the results of scientific in vitro and in vivo experiments focused on the improvement of the healing process of small wounds, hypertrophic scars and burns by C. asiatica. In this paper, we discuss the data on… 
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Chemistry, traditional uses and pharmacological effects of Centella asiatica (L.): A review
TLDR
This perennial creeper has been traditionally used for rheumatism, indigestion, diabetes, dysentery, fever, fractures, hepatitis, jaundice, constipation, wounds, and eye problems and absence of detailed scientific approach hinders the perception of its benefits to develop new drugs.
Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
  • Kyoung-Sik Park
  • Biology, Chemistry
    Evidence-based complementary and alternative medicine : eCAM
  • 2021
TLDR
An understanding of pharmacological studies which confirm the potent dermatological effects and underlying molecular mechanisms of C. asiatica is provided and additional rigorously controlled long-term clinical trials will be necessary to confirm the full potential of the medicinal plant as a therapeutic agent.
The Potential of Centella asiatica (Linn.) Urban as an Anti-Microbial and Immunomodulator Agent: A Review
TLDR
This review attempts to combine the existing literature to offer immense scope for researchers engaged in validation of the traditional claims and bioactivities of this plant related with anti-microbial and immunomodulatory potential.
Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review.
TLDR
More clinical and pharmacokinetic studies are needed to support the use of C. asiatica and its triterpenes as therapeutic agents for cardiovascular diseases, as evidenced by numerous in silico, in vitro, in vivo, and clinical studies.
Spectroscopy Analysis of Antimicrobial Compound in Centella Asiatica Extract
TLDR
The usage of Centella asiatica leaves in society needs to be expanded so that its nutrients can be utilized to the maximum for the benefit of the people and improvement to the national economy.
Integrative Dermatology – The Use of Herbals and Nutritional Supplements to Treat Dermatological Conditions
From humble beginnings at the dawn of time to it’s advanced and successful status today, this essay traces the history of natural medicine and the development of integrated dermatology to what it is…
Botanical Pharmacognosy of Centella asiatica (Linn.)Urban
TLDR
The present macroscopic and histo-anatomical observations of stem, root, stolon, petiole and leaves of Centella asiatica and powder microscopic, quantitative standards put forth could provide useful information for the regulatory aspects of the quality control measures of the crude drugs.
Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model
TLDR
Investigating the anti-dermatitic effects of titrated extract of Centella asiatica in a phthalic anhydride-induced atopic dermatitis animal model as well as in vitro model demonstrated that TECA could be a promising agent for AD by inhibition of NF-κB signaling.
Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica: A Comprehensive Review.
TLDR
Phytochemical constituent and pharmacological activities of CA are focused on based on preclinical and clinical studies, which revealed a wide range of beneficial effects of CA on CNS, cardiovascular, lung, liver, kidney, gastrointestinal, skin, and endocrine system.
Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
TLDR
Comparative tests conducted by corneometer, tewameter and chromameter showed that cosmetic formulations containing Centella asiatica extract have the moisturizing and antiinflammatory properties.
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References

SHOWING 1-10 OF 47 REFERENCES
Centella asiatica in cosmetology
TLDR
Research results indicate that Centella asiatica can be used in the treatment of photoaging skin, cellulite and striae.
Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all
TLDR
The present review attempts to provide comprehensive information on pharmacology, mechanisms of action, various preclinical and clinical studies, safety precautions and current research prospects of Centella asiatica.
Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica.
Hepatotoxicity associated with the ingestion of Centella asiatica.
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TLDR
The presence of autoantibodies and granulomas also favors an immune-mediated mechanism, and Ursodeoxycholic acid has anti-apoptotic properties, but it cannot rule out that Centella asiatica discontinuation alone may have resulted in patient improvement.
Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis.
TLDR
In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture, and a comparison of asiaticoside and as iatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.
Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds.
TLDR
The 3 purified components of TECA were all able to reproduce the effects of the complete drug, with some differences depending on the product, which showed an increased remodeling of the collagen matrix in the wound.
Effect of Centella asiatica L (Umbelliferae) on Normal and Dexamethasone-Suppressed Wound Healing in Wistar Albino Rats
TLDR
The results indicated that the leaf extract of C asiatica promotes wound healing significantly and is able to overcome the wound-healing suppressing action of dexamethasone in a rat model.
Effect of Centella asiatica L
TLDR
It is concluded that C. asiatica L. extract reduced the genotoxic damage during the ethinylestradiol therapy in patients and thereby reducing the chances of cancer development in humans.
In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.
TLDR
Results suggest that the potential use of C. asiatica extracts as a topical anti-psoriatic agent is worthy of further investigation.
Asiaticoside‐induced elevation of antioxidant levels in healing wounds
TLDR
It appears from the present study that asiaticosides enhanced induction of antioxidant levels at an initial stage of healing which may be an important contributory factor in the healing properties of this substance.
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