Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.

@article{Soumyanath2005CentellaAA,
  title={Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.},
  author={Amala Soumyanath and Yong-Ping Zhong and Sandra A Gold and Xiaolin Yu and Dennis R. Koop and Dennis N. Bourdette and Bruce G. Gold},
  journal={The Journal of pharmacy and pharmacology},
  year={2005},
  volume={57 9},
  pages={
          1221-9
        }
}
Axonal regeneration is important for functional recovery following nerve damage. Centella asiatica Urban herb, also known as Hydrocotyle asiatica L., has been used in Ayurvedic medicine for centuries as a nerve tonic. Here, we show that Centella asiatica ethanolic extract (100 microg mL-1) elicits a marked increase in neurite outgrowth in human SH-SY5Y cells in the presence of nerve growth factor (NGF). However, a water extract of Centella was ineffective at 100 microg mL-1. Sub-fractions of… CONTINUE READING

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