Cellulose nanocrystals are effective in inhibiting host cell bacterial adhesion.

@article{DOrazio2017CelluloseNA,
  title={Cellulose nanocrystals are effective in inhibiting host cell bacterial adhesion.},
  author={Giuseppe D'Orazio and L. Munizza and Jessica Zampolli and Matilde Emma Forcella and Luca Zoia and P. Fusi and Patrizia Di Gennaro and Barbara La Ferla},
  journal={Journal of materials chemistry. B},
  year={2017},
  volume={5 34},
  pages={
          7018-7020
        }
}
The use of cellulose nanocrystals (CNCs) as a biomaterial able to inhibit host cell bacterial adhesion is described. Pre-incubation of E. coli ATCC 25922 with a suspension of 0.1% CNCs afforded a significant 2 log reduction of bacterial adhesion to the intestinal cell monolayer HT29. This effect could be attributed to the interaction between the CNCs and the bacterial cell surface as confirmed using fluorescence microscopy experiments. 
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References

SHOWING 1-10 OF 24 REFERENCES
The impact of cellulose nanocrystals on the aggregation and initial adhesion of Pseudomonas fluorescens bacteria.
TLDR
It was observed that bacteria with more EPS aggregated more significantly compared to bacteria with less EPS, and that bacterial deposition under this condition decreased to a greater extent.
Cationic surface functionalization of cellulose nanocrystals
The surface of cellulose nanocrystals, prepared by sulfuric acid hydrolysis of cotton, was rendered cationic through a reaction with epoxypropyltrimethylammonium chloride. The resultant nanocrystal…
Novel Interactions of Glycosaminoglycans and Bacterial Glycolipids Mediate Binding of Enterococci to Human Cells*
TLDR
Results may indicate that heparin and/or heparan sulfate on host epithelial cells and diglucosyldiacylglycerol, either itself or as a partial structure of lipoteichoic acid, are involved in enterococcal adhesion to colonic epithelia, the first step in translocation from the intestinal tract.
Organ Distribution and Bone Tropism of Cellulose Nanocrystals in Living Mice.
TLDR
The results strongly suggest that the peculiar tropism to the bones is due to the chemical interaction between the Ca(2+) of the bone matrix and the active surface of negatively-charged CNCs, which makes C NCs a potential nanodevice for theranostics in bone tumors.
Microbial adherence to and invasion through proteoglycans.
TLDR
The experimental evidence for microbial adhesion to host cell proteoglycans is compelling, and future molecular studies may provide a basis for designing therapeutic strategies based on these interactions.
Flocculation of bacteria by depletion interactions due to rod-shaped cellulose nanocrystals
Heparin blocks the adhesion of E. coli O157:H7 to human colonic epithelial cells.
Interaction of Listeria monocytogenes autolysin amidase with glycosaminoglycans promotes listerial adhesion to mouse hepatocytes.
Force spectroscopy of the interaction between mycobacterial adhesins and heparan sulphate proteoglycan receptors.
TLDR
Atomic force microscopy is used to explore the specific interactions between the heparin-binding hemagglutinin from Mycobacterium tuberculosis, and heparan sulphate proteoglycan receptors on live A549 pneumocytes, and shows that the specific binding forces between single HBHA-HSPG pairs are similar to the forces measured earlier between HBHA andHeparin molecules.
ABILITY OF THE HEPARAN SULFATE PROTEOGLYCAN SYNDECAN-1 TO PARTICIPATE IN BACTERIAL TRANSLOCATION ACROSS THE INTESTINAL EPITHELIAL BARRIER
TLDR
Although E. faecalis, E. coli, and other gram-negative enterobacteria did not appear to interact with syndecan-1, this heparan sulfate proteoglycan may mediate enterocyte interactions with some staphylococci and streptococci that are known to cause systemic infections in specific populations of high-risk, immunosuppressed, postsurgical, and trauma patients.
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