Cellulose hydrolysis in evolving substrate morphologies I: A general modeling formalism.

  title={Cellulose hydrolysis in evolving substrate morphologies I: A general modeling formalism.},
  author={W Zhou and Heinz-Bernd Sch{\"u}ttler and Zhiqian Hao and Yuhan Xu},
  journal={Biotechnology and bioengineering},
  volume={104 2},
We develop a general framework for a realistic rate equation modeling of cellulose hydrolysis using non-complexed cellulase. Our proposed formalism, for the first time, takes into account explicitly the time evolution of the random substrate morphology resulting from the hydrolytic cellulose chain fragmentation and solubilization. This is achieved by integrating novel geometrical concepts to quantitatively capture the time-dependent random morphology, together with the enzymatic chain… CONTINUE READING

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