Cellular versus myocardial basis for the contractile dysfunction of hypertrophied myocardium.

@article{Mann1991CellularVM,
  title={Cellular versus myocardial basis for the contractile dysfunction of hypertrophied myocardium.},
  author={Douglas L. Mann and Yoshitoshi Urabe and R L Kent and Sergio C. Vinciguerra and George Cooper},
  journal={Circulation research},
  year={1991},
  volume={68 2},
  pages={402-15}
}
Contractile dysfunction has been demonstrated in many previous studies of experimental right ventricular pressure-overload hypertrophy; however, given the complex changes that occur both in the cardiac muscle cell and in the multiple components of the cardiac interstitium, it is not clear whether the contractile dysfunction observed is an intrinsic property of the cardiac muscle cell or whether it is the result of a mechanically normal cardiac muscle cell contracting within an abnormal… CONTINUE READING

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