Cellular versus humoral immunology: a century-long dispute

  title={Cellular versus humoral immunology: a century-long dispute},
  author={A. M. Silverstein},
  journal={Nature Immunology},
Historical insight: Immunology's founding fathers argued fiercely about whether Metchnikoff's phagocytes or Ehrlich's antibodies were the most important mediators of immunity. Antibodies won out, but even after lymphocytes re-established cellular immunology, the humoralist-cellularist divide persisted. 

From bacteriology to immunology: the dualism of specificity

The 100th anniversary of Robert Koch's receiving the Nobel Prize reminds us of his achievements as a founder of modern bacteriology and as a forefather of immunology.

The Beginnings of T-B Collaboration

In 1966, at about the same time that Peyton Rouse and Charles Huggins shared the Nobel Prize in Medicine for their discoveries of tumor viruses and hormonal control of carcinoma, respectively,

Living in a Hostile World: Inflammation, New Drug Development, and Coronavirus

An intravenous fluid therapy comprising adenosine, lidocaine and Mg2+ (ALM) that confers a survival advantage by preventing excessive inflammation initiated by sepsis, endotoxemia and sterile trauma is developed.

CD4+ T cell interactions through CD28/B7 molecules affects their Th1/Th2 phenotype

ii Acknowledgements iv Table of contents v List of figures xii Abbreviations xvi Forward xix

The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

Despite scientific controversies, Elie Metchnikoff has allowed the theory of phagocytes to triumph, beautifully defining the role of monocytes, macrophages, and neutrophils during inflammation and innate immunity.

The Mannose-Binding Lectin: An Infection Susceptibility Gene

It is proposed that individuals must have an “immune haplotype” that shapes their response to infectious agents that is a balance between the intrinsic virulence of the infectious agent and the host defenses.

LPS Stimulated B Lymphocytes Inhibit the Differentiation of Th1 Lymphocytes

Evidence for a reciprocal interaction between B and T lymphocyte is emerging, with B lym-phocytes influencing the differentiation and effector function of T lymphocytes.

Manufacturing immunity to disease in a test tube: the magic bullet realized.

Although it took over one hundred years, Ehrlich's concept of the magic bullet is now a reality, the methods developed to accomplish this seemingly formidable task now allow construction of antibodies in a test tube to any antigen.

The history of mast cell and basophil research – some lessons learnt from the last century

Some of the important discoveries and lessons learnt from the last century relating to the function of these two cell types as effectors of the IgE system and the mediators they produce are retrace.



Whatever happened to cell-bound antibodies? On the overriding influence of dogma

For over 75 years, only humoral antibodies were known to mediate immunological specificity. The apparent absence of these in delayed-type hypersensitivity reactions was perplexing, and the dominant

History of immunology.

Immunity to disease has long been recognized, but only during the late nineteenth century, thanks to Louis Pasteur, Robert Koch, Elie Metchnikoff and Paul Ehrlich, did immunology become a true

Paul Ehrlich's Receptor Immunology: The Magnificent Obsession

The Background to Ehrlich's Immunology: Origins of the Receptor Theory and the Side-Chain Theory of Antibody Formation.

Louis Pasteur's beer of revenge

  • A. Baxter
  • Biology, Medicine
    Nature Reviews Immunology
  • 2001
It was the combined efforts of Louis Pasteur and Robert Koch that created the germ theory of disease — the theory that specific microbes cause specific diseases.

Homograft Target Cells: Specific Destruction in vitro by Contact Interaction with Immune Macrophages

Cell destruction apparently resulted from a nonphagocytic mechanism involving cell contact rather than humoral antibody in contact in vitro of immune peritoneal macrophages from C57BI/6K mice with homograft target cells from A/Jax mice.

Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied and elaborated into the medium a soluble material capable of inhibiting migration of normal exudates.