Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein.

@article{Foo2002CellularVA,
  title={Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein.},
  author={N C Foo and Byung Yong Ahn and Xiaohong Ma and William Hyun and T. S. Benedict Yen},
  journal={Hepatology},
  year={2002},
  volume={36 6},
  pages={1400-7}
}
Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive form of viral hepatitis B that occurs in severely immunosuppressed patients. Pathologically, the liver in FCH is characterized by widespread hepatocyte vacuolization and apoptosis, which, in contrast to more common forms of hepatitis B, is only rarely associated with significant inflammation. Therefore, it has been proposed that, in FCH, hepatocytes may be injured by a direct cytopathic effect of the virus rather than by the host… CONTINUE READING

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