Cellular uptake of covalent conjugates of oligonucleotide with membrane-modifying peptide, peptaibol.

Abstract

Using the membrane-modifying peptide, trichorovin-XIIa (TV-XIIa), which is an 11-residual peptaibol isolated from the fungus Trichoderma viride, we synthesized covalent conjugates of 20-mer oligonucleotide with TV-XIIa to examine the potential use of TV-XIIa in cellular delivery. The results indicated that the conjugates were progressively taken up by human… (More)
DOI: 10.1016/j.bmc.2012.03.054

Topics

Cite this paper

@article{Wada2012CellularUO, title={Cellular uptake of covalent conjugates of oligonucleotide with membrane-modifying peptide, peptaibol.}, author={Shun-ichi Wada and Yasunari Hitora and Saori Yokoe and Osamu Nakagawa and Hidehito Urata}, journal={Bioorganic & medicinal chemistry}, year={2012}, volume={20 10}, pages={3219-22} }