Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.

@article{Quadros2013CellularUO,
  title={Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.},
  author={Edward V Quadros and Jeffrey M. Sequeira},
  journal={Biochimie},
  year={2013},
  volume={95 5},
  pages={1008-18}
}
Cellular uptake of cobalamin is facilitated by a receptor-mediated endocytosis process involving transcobalamin, a plasma protein that binds cobalamin and a cell surface receptor that specifically binds transcobalamin saturated with cobalamin. Intracellular Cbl concentration is maintained by modulating the expression of the receptor, which is cell cycle associated with highest expression in actively proliferating cells and an efflux system that shunts the excess cobalamin out of the cells for… CONTINUE READING

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