Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine.

@article{Luedtke2003CellularUO,
  title={Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine.},
  author={N. Luedtke and Peter Carmichael and Y. Tor},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 41},
  pages={
          12374-5
        }
}
Aminoglycosides (including neomycin B and tobramycin) exhibit poor uptake by eukaryotic cell lines. When the amines of these natural products are converted into guanidine groups, their cellular uptake is dramatically enhanced. We have synthesized BODIPY-containing aminoglycosides and guanidinoglycosides to evaluate their cellular uptake properties. Fluorescence activated cell sorting (FACS) and fluorescence microscopy are used to compare the membrane translocation and the cellular localization… Expand
Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes.
Cellular uptake of modified aminoglycosides
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References

SHOWING 1-2 OF 2 REFERENCES
Contrary to experiments conducted with peptide conjugates of small
  • 2002