Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain.

@article{Bolton2000CellularUA,
  title={Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain.},
  author={Sarah J Bolton and Declan N. C. Jones and John G Darker and Drake S. Eggleston and A Jacqueline Hunter and Frank S. Walsh},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 8},
  pages={
          2847-55
        }
}
Investigation of normal and pathological diseases of the central nervous system (CNS) has been hampered by the inability to effectively manipulate protein function in vivo. In order to address this important topic, we have evaluated the ability of penetratin, a novel cell-permeable peptide consisting of a 16-amino acid sequence derived from a Drosophila homeodomain protein, to act as a carrier system to introduce a cargo into brain cells. Fluorescently tagged penetratin was injected directly… CONTINUE READING

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