Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability.

@article{Turner2010CellularUA,
  title={Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability.},
  author={Yvonne Turner and Gerd Wallukat and Pille S{\"a}{\"a}lik and Burkhard Wiesner and Stephan Pritz and Johannes Oehlke},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2010},
  volume={16 1},
  pages={71-80}
}
A 12-mer peptide nucleic acid (PNA) directed against the nociceptin/orphanin FQ receptor mRNA was disulfide bridged with various peptides without and with cell-penetrating features. The cellular uptake and the antisense activity of these conjugates were assessed in parallel. Quantitation of the internalized PNA was performed by using an approach based on… CONTINUE READING