Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

@article{Johnson2002CellularTB,
  title={Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene},
  author={Kristen C. Johnson and Joseph L Kissil and Jessica Lynn Fry and Tyler 8 Jacks},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={5990-5997}
}
Mutations in the Nf2 tumor suppressor gene lead to tumor formation in humans and mice and cellular overproliferation phenotypes in Drosophila. The Nf2 encoded protein, merlin, shares close sequence similarity in its amino terminus to members of the band 4.1 family of membrane-cytoskeletal linkers. Similarities between merlin and this family suggest a role for merlin in regulating cytoskeletal function. However, the mechanism of the tumor suppressing activity of merlin is not yet understood… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 17 REFERENCES

J

  • S Tsukita, K Oishi, N Sato, J Sagara, A. Kawai
  • Cell. Biol., 126, 391 – 401.
  • 1994
Highly Influential
16 Excerpts

J

  • T Shimizu, A Seto, N Maita, K Hamada, S Tsukita, T. Hakoshima
  • Biol. Chem., 276, 52.
  • 2001

Am

  • RP Stokowski, Cox DR.
  • J. Hum. Genet., 66, 873 – 891.
  • 2000

Exp

  • AA Schmitz, EE Govek, B Bottner, L. Van Aelst
  • Cell Res., 261, 1 – 12.
  • 2000
1 Excerpt

Hum

  • DH Gutmann, L Sherman, L Seftor, C Haipek, K Hoang Lu, M. Hendrix
  • Mol. Genet., 8, 267 – 275.
  • 1999

J

  • DH Gutmann, CA Haipek, K. Hoang Lu
  • Neurosci. Res., 58, 706 – 716.
  • 1999

Am

  • JA Harwalkar, JH Lee, G Hughes, SE Kinney, M. Golubic
  • J. Otol., 19, 654 – 659.
  • 1998
2 Excerpts

J

  • DR LaJeunesse, BM McCartney, RG. Fehon
  • Cell. Biol., 141, 1589 – 1599.
  • 1998

J

  • VJ Obremski, AM Hall, C. Fernandez-Valle
  • Neurobiol., 37, 487 – 501.
  • 1998

J

  • AB Vojtek, Der CJ.
  • Biol. Chem., 273, 19925 – 19928.
  • 1998

Similar Papers

Loading similar papers…