Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.

@article{Cheng2009CellularTB,
  title={Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.},
  author={Jingwei Cheng and James A. DeCaprio and Michele M. Fluck and Brian S. Schaffhausen},
  journal={Seminars in cancer biology},
  year={2009},
  volume={19 4},
  pages={
          218-28
        }
}
Simian Virus 40 (SV40) and Mouse Polyoma Virus (PY) are small DNA tumor viruses that have been used extensively to study cellular transformation. The SV40 early region encodes three tumor antigens, large T (LT), small T (ST) and 17KT that contribute to cellular transformation. While PY also encodes LT and ST, the unique middle T (MT) generates most of the transforming activity. SV40 LT mediated transformation requires binding to the tumor suppressor proteins Rb and p53 in the nucleus and ST… CONTINUE READING
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