Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.

@article{Ruben1988CellularTF,
  title={Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.},
  author={Steven M. Ruben and H T Poteat and Teresita Tan and Kimihiro Kawakami and Robert Roeder and William A. Haseltine and Craig A. Rosen},
  journal={Science},
  year={1988},
  volume={241 4861},
  pages={89-92}
}
Expression of the interleukin-2 receptor (IL-2R alpha) gene is activated by the transcriptional activator protein, Tax (previously referred to as the tat gene product), encoded by the human T-cell leukemia virus (HTLV-I). Multiple protein binding sites for specific DNA-protein interactions were identified over the upstream IL-2R alpha transcriptional regulatory sequences. However, only one region, which includes the sequence motif GGGGAATCTCCC, was required for activation by both the tax gene… CONTINUE READING