Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation.

@article{Khalil2014CellularTF,
  title={Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation.},
  author={Mohamed Ibrahim Khalil and Marvin H Sommer and Ann Margaret Arvin and John G Hay and William T. Ruyechan},
  journal={Virology},
  year={2014},
  volume={449},
  pages={244-53}
}
Several cellular transcription factors have been shown to be involved in IE62-mediated activation. The YY1 cellular transcription factor has activating and repressive effects on gene transcription. Analysis of the VZV genome revealed 19 postulated YY1 binding sites located within putative promoters of 16 VZV genes. Electrophoretic mobility shift assays (EMSA) confirmed the binding of YY1 to ORF10, ORF28/29 and gI promoters and the mutation of these binding sites inhibited YY1 binding and the… CONTINUE READING