Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells.

@article{Kim2018CellularTD,
  title={Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells.},
  author={Tae-Jun Kim and J Byun and Hyun Sook Kwon and Do-yeon Kim},
  journal={Biochemical and biophysical research communications},
  year={2018},
  volume={497 1},
  pages={347-353}
}
As a powerful antioxidant, vitamin C protects cells from oxidative damage by inhibiting production of free radicals. However, high levels of vitamin C shows cytotoxicity especially on cancerous cells through generating excessive ROS and blocking the energy homeostasis. Although the double-sided character of vitamin C has been extensively studied in many… CONTINUE READING