Cellular therapy for childhood neurodegenerative disease. Part II: clinical trial design and implementation.

@article{Selden2008CellularTF,
  title={Cellular therapy for childhood neurodegenerative disease. Part II: clinical trial design and implementation.},
  author={Nathan R W Selden and Daniel J. Guillaume and Robert D Steiner and Stephen L Huhn},
  journal={Neurosurgical focus},
  year={2008},
  volume={24 3-4},
  pages={E23}
}
Cellular replacement therapy attempts to improve functioning of the diseased human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation… CONTINUE READING

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