Cellular stress response pathways and ageing: intricate molecular relationships.

@article{Kourtis2011CellularSR,
  title={Cellular stress response pathways and ageing: intricate molecular relationships.},
  author={N Kourtis and Nektarios Tavernarakis},
  journal={The EMBO journal},
  year={2011},
  volume={30 13},
  pages={2520-31}
}
Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules vital for proper cellular function. Although this process is fundamentally haphazard and uncontrollable, senescent decline and ageing is broadly influenced by genetic and extrinsic factors. Numerous gene mutations and treatments have been shown to extend the lifespan of diverse organisms ranging from the unicellular Saccharomyces cerevisiae to primates. It is becoming increasingly apparent that most such… CONTINUE READING

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