Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer

Abstract

Expression of the Notch ligand JAG1 and Notch pathway activation promote poor prognosis, basal-like breast cancer. We have recently shown that the pseudokinase Tribbles homolog 3 (TRB3) regulates JAG1 expression in this malignancy. TRB3 is a stress and metabolic sensor, and here we show that nutrient deprivation or endoplasmic reticulum stress markedly… (More)
DOI: 10.1038/onc.2016.276

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