Cellular stress failure in ventilator-injured lungs.

@article{Vlahakis2005CellularSF,
  title={Cellular stress failure in ventilator-injured lungs.},
  author={Nicholas E. Vlahakis and Rolf D. Hubmayr},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={171 12},
  pages={1328-42}
}
The clinical and experimental literature has unequivocally established that mechanical ventilation with large tidal volumes is injurious to the lung. However, uncertainty about the micromechanics of injured lungs and the numerous degrees of freedom in ventilator settings leave many unanswered questions about the biophysical determinants of lung injury. In this review we focus on experimental evidence for lung cells as injury targets and the relevance of these studies for human ventilator… CONTINUE READING

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