Cellular strategies for controlling protein aggregation

@article{Tyedmers2010CellularSF,
  title={Cellular strategies for controlling protein aggregation},
  author={J. Tyedmers and A. Mogk and B. Bukau},
  journal={Nature Reviews Molecular Cell Biology},
  year={2010},
  volume={11},
  pages={777-788}
}
The aggregation of misfolded proteins is associated with the perturbation of cellular function, ageing and various human disorders. Mounting evidence suggests that protein aggregation is often part of the cellular response to an imbalanced protein homeostasis rather than an unspecific and uncontrolled dead-end pathway. It is a regulated process in cells from bacteria to humans, leading to the deposition of aggregates at specific sites. The sequestration of misfolded proteins in such a way is… Expand
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References

SHOWING 1-10 OF 170 REFERENCES
Specificity in intracellular protein aggregation and inclusion body formation
  • 218
  • PDF
Protein degradation and protection against misfolded or damaged proteins
  • 1,861
  • PDF
Molecular Chaperones and Protein Quality Control
  • 1,343
Polyglutamine protein aggregates are dynamic
  • 292
  • PDF
Aggresomes: A Cellular Response to Misfolded Proteins
  • 2,032
  • PDF
...
1
2
3
4
5
...