Cellular strain amplifies lps-induced stress signaling in immature enterocytes: potential implications for preterm infant nasal CPAP

@inproceedings{Alcamo2012CellularSA,
  title={Cellular strain amplifies lps-induced stress signaling in immature enterocytes: potential implications for preterm infant nasal CPAP},
  author={Alicia M. Alcamo and Brandon L. Schanbacher and Hong Huang and Craig A. Nankervis and John Anthony Bauer and Peter J. Giannone},
  booktitle={Pediatric Research},
  year={2012}
}
Background:Recent clinical observations of increased necrotizing enterocolitis (NEC) incidence in some nasal continuous positive airway pressure (NCPAP) patients raise concerns about whether the related abdominal distension is benign or contributes to NEC. We tested the hypothesis that mechanical strain causes an exaggerated enterocyte inflammatory response and decreased enterocyte growth and proliferation in the absence and presence of lipopolysaccharide (LPS).Methods:First we used a confluent… CONTINUE READING

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