Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct.

@article{Hbert1994CellularSO,
  title={Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct.},
  author={Richard L. H{\'e}bert},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1994},
  volume={51 3},
  pages={147-55}
}
We have documented new observations with respect to PGE2 action in the rabbit CCD. (1) PGE2 can inhibit both cAMP and vasopressin-induced water flow, depending on the sequence of PGE2 addition with respect to vasopressin or cAMP. (2) PGE2 inhibition of vasopressin or cAMP-stimulated water flow can be reversed with staurosporine. Thus, PGE2 inhibits vasopressin-stimulated water flow by activation of PKC and (3) PGE2 induces release of calcium from intracellular stores. These results strongly… CONTINUE READING

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