Cellular signaling of Dock family proteins in neural function.

  title={Cellular signaling of Dock family proteins in neural function.},
  author={Yuki Miyamoto and Junji Yamauchi},
  journal={Cellular signalling},
  volume={22 2},
Dock180-related proteins are genetically conserved from Drosophila and C. elegans to mammals and are atypical types of guanine-nucleotide exchange factors (GEFs) for Rac and/or Cdc42 of small GTPases of the Rho family. Eleven members of the family occur in mammalian cells, each playing key roles in many aspects of essential cellular functions such as regulation of cytoskeletal organization, phagocytosis, cell migration, polarity formation, and differentiation. This review will summarize the… CONTINUE READING