Cellular senescence of human mammary epithelial cells (HMEC) is associated with an altered MMP-7/HB-EGF signaling and increased formation of elastin-like structures

@article{Bertram2009CellularSO,
  title={Cellular senescence of human mammary epithelial cells (HMEC) is associated with an altered MMP-7/HB-EGF signaling and increased formation of elastin-like structures},
  author={Catharina Bertram and Ralf Hass},
  journal={Mechanisms of Ageing and Development},
  year={2009},
  volume={130},
  pages={657-669}
}
  • C. Bertram, R. Hass
  • Published 1 October 2009
  • Biology
  • Mechanisms of Ageing and Development
View on Elsevier
doi.org
30 Citations
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30 Citations

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Findings suggested an MSC-mediated growth stimulation of breast cancer cells in vitro and in vivo by which the altered MSC morphology and the appearance of hybrid/chimeric cells and breast cancer-expressing CD90(+) cells indicate mutual cellular alterations.
Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis
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A cell-targeted genetic approach has revealed a previously unrecognized role of the PDGFA/PDGFRa axis, mediated through a complex and interdependent cross regulatory network of multiple signaling pathways that converge to regulate postnatal alveologenesis.
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Fusion with necrotic/apoptotic tumor cell bodies contributes to re-program MSC into an aberrant phenotype also suggesting that tumor tissue in general represents different types of neoplastic cell populations including tumor-associated stem cell-like cells.
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