Cellular senescence limits regenerative capacity and allograft survival.


Long-term graft survival after kidney transplantation remains unsatisfactory and unpredictable. Interstitial fibrosis and tubular atrophy are major contributors to late graft loss; features of tubular cell senescence, such as increased p16(INK4a) expression, associate with these tubulointerstitial changes, but it is unknown whether the relationship is… (More)
DOI: 10.1681/ASN.2011100967

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