Cellular senescence induced loss of stem cell proportion in the skin in vitro.

Abstract

BACKGROUND It is known that cellular senescence could affect culture results. A previous study on K19 found that the loss of stem cell proportion is the reason for difficulties experienced when culturing aged keratinocytes. But the situation is unclear, because K19 is not generally accepted as an epidermal stem cell marker. OBJECTIVE The aim of this study… (More)

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