Cellular senescence induced by p53‐ras cooperation is independent of p21waf1 in murine embryo fibroblasts

@article{Castro2004CellularSI,
  title={Cellular senescence induced by p53‐ras cooperation is independent of p21waf1 in murine embryo fibroblasts},
  author={M. Castro and M. Guijarro and V. Moneo and A. Carnero},
  journal={Journal of Cellular Biochemistry},
  year={2004},
  volume={92}
}
Oncogenic activation in primary murine fibroblasts initiates a senescence‐like cell cycle arrest that depends on the p53 tumor suppressor pathway. Conditional p53 activation efficiently induced a reversible cell cycle arrest but was unable to induce features of senescence. In contrast, coexpression of oncogenic ras with p53 produced an irreversible cell cycle arrest that displayed features of cellular senescence. Introduction of a conditional murine p53 allele (p53val135) into double p53/p21… Expand
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