Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies.

@article{Zhu2007CellularSI,
  title={Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies.},
  author={Chun-Hong Zhu and Vincent Mouly and Racquel N. Cooper and Kamel Mamchaoui and Anne Bigot and Jerry W Shay and James P Di Santo and Gillian Butler-Browne and Woodring E Wright},
  journal={Aging cell},
  year={2007},
  volume={6 4},
  pages={515-23}
}
Cultured human myoblasts fail to immortalize following the introduction of telomerase. The availability of an immortalization protocol for normal human myoblasts would allow one to isolate cellular models from various neuromuscular diseases, thus opening the possibility to develop and test novel therapeutic strategies. The parameters limiting the efficacy of myoblast transfer therapy (MTT) could be assessed in such models. Finally, the presence of an unlimited number of cell divisions, and thus… CONTINUE READING

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The Authors Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain

  • Immortal human myoblasts, C.-H. Zhu
  • 2007

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