Cellular senescence in cancer treatment: friend or foe?

  title={Cellular senescence in cancer treatment: friend or foe?},
  author={Pascal Kahlem and Bernd Doerken and Clemens A. Schmitt},
  journal={The Journal of clinical investigation},
  volume={113 2},
Damage to DNA, the prime target of anticancer therapy, triggers programmed cellular responses. In addition to apoptosis, therapy-mediated premature senescence has been identified as another drug-responsive program that impacts the outcome of cancer therapy. Here, we discuss whether induction of senescence is a beneficial or, rather, a detrimental consequence of the therapeutic intervention. 

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