Cellular senescence: hot or what?


The phenomenon of replicative senescence was first observed more than 40 years ago by Hayflick who noted the inability of cultured human fibroblasts to proliferate indefinitely. The recent discovery that cellular senescence is triggered by many different activated oncogenes has led to the notion that senescence, like oncogene-induced apoptosis, serves as a… (More)
DOI: 10.1016/j.gde.2008.11.009


Cite this paper

@article{Evan2009CellularSH, title={Cellular senescence: hot or what?}, author={Gerard I. Evan and Fabrizio d'Adda di Fagagna}, journal={Current opinion in genetics & development}, year={2009}, volume={19 1}, pages={25-31} }