Cellular senescence: when bad things happen to good cells

@article{Campisi2007CellularSW,
  title={Cellular senescence: when bad things happen to good cells},
  author={Judith Campisi and Fabrizio d'Adda di Fagagna},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={729-740}
}
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex… Expand

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References

SHOWING 1-10 OF 201 REFERENCES
What has senescence got to do with cancer?
TLDR
A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy. Expand
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
TLDR
The senescence response may be antagonistically pleiotropic, promoting early-life survival by curtailing the development of cancer but eventually limiting longevity as dysfunctional senescent cells accumulate. Expand
Oncogene-induced senescence: putting the brakes on tumor development.
TLDR
A number of recent studies now show the effect of this acute and telomere-independent form of senescence as a tumor-protective, fail-safe mechanism in vivo that shares conceptual and possibly therapeutic similarities with the genetically encoded apoptosis machinery. Expand
Cellular senescence as a tumor-protection mechanism: the essential role of counting.
  • W. Wright, J. Shay
  • Biology, Medicine
  • Current opinion in genetics & development
  • 2001
TLDR
Increasing understanding of the role of telomere shortening in the replicative aging of cultured fibroblasts now permits a re-examination of what may reasonably be called cellular senescence, and what most likely represents artifacts of the culture environment and/or specific cell-cycle control mechanisms. Expand
Cellular senescence as a tumor-suppressor mechanism.
TLDR
Findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism. Expand
Hallmarks of senescence in carcinogenesis and cancer therapy
TLDR
The emerging knowledge about the pathways that lead to senescence and determine the pattern of gene expression in senescent cells may lead to more effective treatments for cancer. Expand
Differential regulation of apoptotic cell death in senescent human cells
Aging of human cells can be reproduced in monolayer cultures, revealing the phenotype of replicative senescence. It was shown that diploid human fibroblasts enter a stable growth arrest phenotype atExpand
Tumour biology: Senescence in premalignant tumours
TLDR
It is shown that senescent cells exist in premalignant tumours but not in malignant ones, and that senescence is therefore a defining feature of premalign tumours that could prove valuable in the diagnosis and prognosis of cancer. Expand
Mechanisms of cellular senescence in human and mouse cells
TLDR
This Review article categorizes cellular senescence into two types, focuses on the differences between human and mouse cells, and discusses the roles of the p53 and pRb tumor suppressor pathways in cellularsenescence. Expand
Cancer and ageing: rival demons?
  • J. Campisi
  • Biology, Medicine
  • Nature Reviews Cancer
  • 2003
TLDR
The shift from developmental and/or germline maintenance in simple organisms to somatic maintenance in complex organisms might have evolved at a cost, and recent evidence indicates that some mammalian tumour-suppressor mechanisms contribute to ageing. Expand
...
1
2
3
4
5
...