Cellular senescence: from physiology to pathology

@article{MuozEspn2014CellularSF,
  title={Cellular senescence: from physiology to pathology},
  author={Daniel Mu{\~n}oz-Esp{\'i}n and Manuel Serrano},
  journal={Nature Reviews Molecular Cell Biology},
  year={2014},
  volume={15},
  pages={482-496}
}
Recent discoveries are redefining our view of cellular senescence as a trigger of tissue remodelling that acts during normal embryonic development and upon tissue damage. To achieve this, senescent cells arrest their own proliferation, recruit phagocytic immune cells and promote tissue renewal. This sequence of events — senescence, followed by clearance and then regeneration — may not be efficiently completed in aged tissues or in pathological contexts, thereby resulting in the accumulation of… CONTINUE READING
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