Cellular responses to DNA damage: one signal, multiple choices.

  title={Cellular responses to DNA damage: one signal, multiple choices.},
  author={Tin Tin Su},
  journal={Annual review of genetics},
  • Tin Tin Su
  • Published 2006 in Annual review of genetics
DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs. 

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