Cellular responses and repair of single-strand breaks introduced by UV damage endonuclease in mammalian cells.

@article{Okano2000CellularRA,
  title={Cellular responses and repair of single-strand breaks introduced by UV damage endonuclease in mammalian cells.},
  author={Satoshi Okano and Shin-ichiro Kanno and Satoshi Nakajima and Akira Yasui},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 42},
  pages={
          32635-41
        }
}
Although single-strand breaks (SSBs) occur frequently, the cellular responses and repair of SSB are not well understood. To address this, we established mammalian cell lines expressing Neurospora crassa UV damage endonuclease (UVDE), which introduces a SSB with a 3'-OH immediately 5' to UV-induced cyclobutane pyrimidine dimers or 6-4 photoproducts and initiates an alternative excision repair process. Xeroderma pigmentosum group A cells expressing UVDE show UV resistance of almost the wild-type… CONTINUE READING
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