Cellular response to reperfused oxygen in the postischemic myocardium.

  title={Cellular response to reperfused oxygen in the postischemic myocardium.},
  author={Youngran Chung and Thomas Jue},
  journal={The American journal of physiology},
  volume={271 2 Pt 2},
Perfused rat heart experiments focused on determining the critical O2 level in postischemic myocardium. After a 20-min global ischemia, reperfusion began with O2-saturated saline buffer reflowing at different rates (0.5-12 ml/min). The 1H nuclear magnetic resonance (NMR) signal of the Val E11 myoglobin (Mb) gave an index of the intracellular oxygenation, whereas the 31P-NMR spectra reflected the high-energy phosphate and pH status. At the same time, physiological monitors recorded both… CONTINUE READING