Cellular response to DNA damage.

@article{Kao2005CellularRT,
  title={Cellular response to DNA damage.},
  author={J. W. Kao and Barry Rosenstein and Sheila Peters and Michael Milano and Stephen J Kron},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1066},
  pages={
          243-58
        }
}
Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non-homologous end-joining, and homologous recombination. Defects in DNA repair processes generally result in susceptibility to cancer and, often, abnormalities in multiple organ systems. While signal… CONTINUE READING
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