Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death.

Abstract

DNA topoisomerase inhibitors are important antineoplastic agents used in the treatment of both leukemias and solid tumors, such as breast, lung and colon cancers. Their clinical usefulness is limited by both natural and acquired tumor cell resistance, which almost always is multifactorial in nature. The resistance can be due to pretarget events, such as… (More)

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@article{Larsen1998CellularRT, title={Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death.}, author={Annette Kragh Larsen and Andrzej C. Skladanowski}, journal={Biochimica et biophysica acta}, year={1998}, volume={1400 1-3}, pages={257-74} }