Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.

@article{Yang1997CellularRP,
  title={Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.},
  author={Charles C. Yang and Xiao Xiao and Xiaodong Zhu and David C Ansardi and Neal D. Epstein and Mark R. Frey and A Gregory Matera and Richard Jude Samulski},
  journal={Journal of virology},
  year={1997},
  volume={71 12},
  pages={9231-47}
}
The human parvovirus adeno-associated virus (AAV) is unique in its ability to target viral integration to a specific site on chromosome 19 (ch-19). Recombinant AAV (rAAV) vectors retain the ability to integrate but have apparently lost this ability to target. In this report, we characterize the terminal-repeat-mediated integration for wild-type (wt), rAAV, and in vitro systems to gain a better understanding of these differences. Cell lines latent for either wt or rAAV were characterized by a… CONTINUE READING
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