Cellular receptor for poliovirus: Molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily

@article{Mendelsohn1989CellularRF,
  title={Cellular receptor for poliovirus: Molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily},
  author={Cathy Lee Mendelsohn and Eckard Wimmer and Vincent R. Racaniello},
  journal={Cell},
  year={1989},
  volume={56},
  pages={855-865}
}
Restriction of poliovirus replication to a few sites in the infected primate host appears to be controlled by the expression of viral receptors. To learn more about these binding sites and their role in viral tissue tropism, cDNA clones encoding functional poliovirus receptors were isolated. The predicted amino acid sequence reveals that the human poliovirus receptor is an integral membrane protein with the conserved amino acids and domain structure characteristic of members of the… 
Heterogeneous expression of poliovirus receptor-related proteins in human cells and tissues
Portions of the cellular receptor for poliovirus were expressed in Escherichia coli as fusion proteins with the product of the trpE gene. One of two antireceptor antisera obtained by immunizing
Mutational analysis of the cellular receptor for poliovirus
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The results show that immunoglobulin-type domain 3 and the extreme carboxy terminus of the PVR are not required for viral receptor function, but sequences within the two amino-terminal domains contribute to the initiation of poliovirus infection.
The Promoters for Human and Monkey Poliovirus Receptors
TLDR
Results suggest that the cis-element(s) governing cell type-specific hPVR expression resides in the minimal promoter region, and the sequences of the promoters of two monkey homologues to hPvr (AGMα1 and AGMα2).
Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene
TLDR
Identification of the ligand and the cellular function of the Mph protein may help to understand the role of Pvr in the cell and build pvr-mph chimeras to identify the contact points of poliovirus within domain 1 of PvR.
Methods for the use of poliovirus vectors for gene delivery.
TLDR
The availability of a transgenic mouse expressing the poliovirus receptor has facilitated further description of the pathogenesis of Poliovirus and the entire nucleic acid sequence of poliov virus has been determined.
The soluble form of two N-terminal domains of the poliovirus receptor is sufficient for blocking viral infection.
TLDR
The experiments suggest that the two N-terminal domains of the poliov virus receptor in soluble form are sufficient for the conversion of poliovirus into a non-infectious particle.
The Human Poliovirus Receptor
TLDR
Diffuse PV encephalomyelitis in wild-type mice could be distinguished clinically and histopathologically from hPVR-mediatedPoliovirus infection in trangenic mice and mouse neuropathogenicity could possibly be conferred by reduced particle stability of PV1(LS-a) inasmuch as the authors found particles to be thermolabile.
Homolog-scanning mutagenesis reveals poliovirus receptor residues important for virus binding and replication
TLDR
Results of virus alteration assays indicate that this chimeric receptor is defective in converting native virus to 135S altered particles, suggesting that poliovirus-induced cytopathic effect may be induced by the virus-receptor interaction.
Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene.
TLDR
A human PVR-related (PRR) cDNA has been isolated and has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa.
A chimeric poliovirus/CD4 receptor confers susceptibility to poliovirus on mouse cells
TLDR
Data are presented showing that transfer of the putative poliov virus receptor-binding domain to a truncated receptor for the human immunodeficiency virus results in a functional receptor for poliovirus.
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References

SHOWING 1-10 OF 45 REFERENCES
Transformation of a human poliovirus receptor gene into mouse cells.
TLDR
Results suggest that DNA encoding the HeLa cell poliov virus receptor has been introduced into mouse cells, resulting in the expression of the receptor and susceptibility to poliovirus infection.
Evidence for the direct involvement of the rhinovirus canyon in receptor binding.
TLDR
Evidence is presented that indicates a deep crevice located on the surface of human rhinovirus type 14 is involved in virion attachment to cellular receptors and single amino acid substitutions or insertions at positions 103, 155, 220, 223, and 273 of the structural protein VP1 create mutants.
Monoclonal antibodies which block cellular receptors of poliovirus.
TLDR
It is concluded that the antibodies are directed against the receptor site for poliovirus which is distinct from those required by other picornaviruses, and which seems to be antigenically well conserved between cells of human and primate origin.
The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes
TLDR
The sequence of the cDNA reveals that T8 is a transmembrane protein with an N-terminal domain which shares significant homology to immunoglobulin variable region light chains, likely to be important in the function of T8 during differentiation and in the course of the immune response.
Mapping of sequences required for mouse neurovirulence of poliovirus type 2 Lansing
TLDR
The ability of Lansing virus to cause paralysis in mice is due to the viral capsid, and the complete nucleotide sequence of the Lansing viral genome from cloned cDNA was determined.
Production of a monoclonal antibody against an epitope on HeLa cells that is the functional poliovirus binding site.
TLDR
Results indicate that D171 recognizes the poliov virus receptor site on different susceptible cells and that practically all D171 binding sites are involved in the specific attachment of poliovirus to the plasma membrane.
Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment.
TLDR
Results strongly suggest that the 100-kDa band detected by antibody AF3 is, or is closely associated with, the poliovirus receptor site.
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
TLDR
The studies support a mechanism of AIDS virus infection that initially involves the specific interaction of theAIDS virus with T4 molecules on the cell surface, and find that the T4 gene is expressed in the brain as well as in lymphoid cells, providing an explanation for the dual neurotropic and lymphotropic character of the AIDS virus.
The major human rhinovirus receptor is ICAM-1
TLDR
The major human rhinovirus receptor has been identified with monoclonal antibodies that inhibit rhInovirus infection and protein sequence from the 95 kd protein showed an identity with that of intercellular adhesion molecule-1 (ICAM-1).
Receptor affinities as major determinants of enterovirus tissue tropisms in humans.
TLDR
The wide range of enterovirus susceptibility of most human cells after in vitro cultivation appears to be a consequence of receptor synthesis in vitro -a function which is normally repressed in most cells in their differentiated state in the body.
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