Cellular proteins mediate 5'-3' end contacts of Norwalk virus genomic RNA.

@article{SandovalJaime2009CellularPM,
  title={Cellular proteins mediate 5'-3' end contacts of Norwalk virus genomic RNA.},
  author={Carlos Sandoval-Jaime and Ana Lorena Guti{\'e}rrez-Escolano},
  journal={Virology},
  year={2009},
  volume={387 2},
  pages={322-30}
}
Long-range RNA-RNA interactions between the 5' and 3' ends are a common feature involved in the regulation of both the initiation of translation and the synthesis of the viral genomic RNAs. These interactions either take place by direct RNA-RNA contacts or can be mediated by proteins. By in silico analysis, we found three possible complementary sequences (CS) between the 5' and the 3' ends of the Norwalk virus genomic RNA. Co-precipitation assays demonstrated that physical contacts between the… CONTINUE READING