Cellular protein modulates effects of human immunodeficiency virus type 1 Rev.

@article{Luo1994CellularPM,
  title={Cellular protein modulates effects of human immunodeficiency virus type 1 Rev.},
  author={Yang Luo and Hong Yu and B Matija Peterlin},
  journal={Journal of virology},
  year={1994},
  volume={68 6},
  pages={3850-6}
}
Replication of human immunodeficiency virus type 1 requires expression of the viral trans activator Rev. Rev binds to a highly structured RNA, the Rev response element, which is present in singly spliced and unspliced genomic viral RNAs. Although Rev helps to transport these transcripts from the nucleus to the cytoplasm, the mechanism(s) involved is not fully understood. Using the yeast two-hybrid system, we isolated a murine protein (YL2) that interacts with the basic domain of Rev, which is… CONTINUE READING

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