Cellular processing of platinum anticancer drugs

  title={Cellular processing of platinum anticancer drugs},
  author={D. Wang and S. Lippard},
  journal={Nature Reviews Drug Discovery},
  • D. Wang, S. Lippard
  • Published 2005
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum drugs. This review focuses on recently discovered cellular pathways that are activated in response to cisplatin, including those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle… CONTINUE READING
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