Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan.

@article{Zakrzewska2007CellularPA,
  title={Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan.},
  author={Anna Zakrzewska and Andr{\'e} Boorsma and Daniela Delneri and Stanley Brul and Stephen G. Oliver and Frans Klis},
  journal={Eukaryotic cell},
  year={2007},
  volume={6 4},
  pages={
          600-8
        }
}
Global fitness analysis makes use of a genomic library of tagged deletion strains. We used this approach to study the effect of chitosan, which causes plasma membrane stress. The data were analyzed using T-profiler, which was based on determining the sensitivities of groups of deletion strains to chitosan, as defined by Gene Ontology (GO) and by genomic synthetic lethality screens, in combination with t statistics. The chitosan-hypersensitive groups included a group of deletion strains… CONTINUE READING

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