Cellular prion protein is expressed in a subset of neuroendocrine cells of the rat gastrointestinal tract.

@article{Marcos2004CellularPP,
  title={Cellular prion protein is expressed in a subset of neuroendocrine cells of the rat gastrointestinal tract.},
  author={Zuberoa Marcos and Kristine Pffeifer and Maria Elena Bodegas and Mar{\'i}a P. Sesma and Laura Guembe},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2004},
  volume={52 10},
  pages={1357-65}
}
Prion diseases are believed to develop from the conformational change of normal cellular prion protein (PrPc) to a pathogenic isoform (PrPsc). PrPc is present in both the central nervous system and many peripheral tissues, although protein concentration is significantly lower in non-neuronal tissues. PrPc expression is essential for internalization and replication of the infectious agent. Several works have pointed to the gastrointestinal (GI) tract as the principal site of entry of PrPsc, but… CONTINUE READING

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