Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

@article{Kudo2012CellularPP,
  title={Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.},
  author={Wataru Kudo and Hyun-pil Lee and Wen-Quan Zou and Xinglong Wang and George Perry and Xiongwei Zhu and Mark A. Smith and Robert Bob Petersen and Hyoung-Gon Lee},
  journal={Human molecular genetics},
  year={2012},
  volume={21 5},
  pages={1138-44}
}
In Alzheimer disease (AD), amyloid-β (Aβ) oligomer is suggested to play a critical role in imitating neurodegeneration, although its pathogenic mechanism remains to be determined. Recently, the cellular prion protein (PrP(C)) has been reported to be an essential co-factor in mediating the neurotoxic effect of Aβ oligomer. However, these previous studies focused on the synaptic plasticity in either the presence or the absence of PrP(C) and no study to date has reported whether PrP(C) is required… CONTINUE READING
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