Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells

@article{Roucou2005CellularPP,
  title={Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells},
  author={Xavier Roucou and Paresa N. Giannopoulos and Y Zhang and Julie Jodoin and Cynthia Gates Goodyer and Andrea M Leblanc},
  journal={Cell Death and Differentiation},
  year={2005},
  volume={12},
  pages={783-795}
}
Prion protein (PrP) prevents Bcl-2-associated protein X (Bax)-mediated cell death, but the step at which PrP inhibits is not known. We first show that PrP is very specific for Bax and cannot prevent Bak (Bcl-2 antagonist killer 1)-, tBid-, staurosporine- or thapsigargin-mediated cell death. As Bax activation involves Bax conformational change, mitochondrial translocation, cytochrome c release and caspase activation, we investigated which of these events was inhibited by PrP. PrP inhibits Bax… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

Potential roles for prions and protein-only inheritance in cancer

Cancer and Metastasis Reviews • 2011
View 14 Excerpts
Highly Influenced

Negative regulation of apoptosis in yeast.

Biochimica et biophysica acta • 2008
View 11 Excerpts
Highly Influenced

Prion protein lacks robust cytoprotective activity in cultured cells

Molecular Neurodegeneration • 2008
View 4 Excerpts
Highly Influenced

The normal cellular prion protein and its possible role in angiogenesis.

Frontiers in bioscience : a journal and virtual library • 2008
View 7 Excerpts
Highly Influenced

Prion Protein Family Contributes to Tumorigenesis via Multiple Pathways.

Advances in experimental medicine and biology • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…