Cellular players in lung fibrosis.

  title={Cellular players in lung fibrosis.},
  author={Annemarie N. Lekkerkerker and Jamil Aarbiou and Thomas van Es and Richard A. J. Janssen},
  journal={Current pharmaceutical design},
  volume={18 27},
Pathogenic mechanisms involved in fibrosis of various organs share many common features. Myofibroblasts are thought to play a major role in fibrosis through excessive deposition of extracellular matrix during wound healing processes. Myofibroblasts are observed in fibrotic lesions, and whereas these derive from the hepatic stellate cells in liver, in lung they appear to originate from fibroblasts. The source of these fibroblasts has been the object of numerous studies over the recent years and… CONTINUE READING

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