Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines

@article{Consoli1997CellularPO,
  title={Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines},
  author={Ugo Consoli and N V Van and Nouri Neamati and R K Mahadevia and Miloslav E Beran and Shourong Zhao and Michael Andreeff},
  journal={Leukemia},
  year={1997},
  volume={11},
  pages={2066-2074}
}
Previous reports suggest that resistance to mitoxantrone in different tumor cell lines is unrelated to the overexpression of p-glycoprotein. In order to determine the role of p-glycoprotein in the cellular pharmacology of mitoxantrone flow cytometry and confocal microscopy were used to study two human myeloid leukemia cell lines selected for resistance to mitoxantrone (HL-60MX2) and doxorubicin (HL-60DOX). To optimize the detection of intracellular mitoxantrone, we determined the maximum… CONTINUE READING

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